a Record control number S089970711300017X

a ISSN 0899-7071

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WL355

b Item number .U85 2013

a Personal name Alıcıoglu, Banu.

h Medium Electronic Document

a Title Utility of semiquantitative parameters to differentiate benign and malignant focal hepatic lesions

c Statement of responsibility, etc Banu Alıcıoglu, OmerTolga Guler, Nail Bulakbası, Suha Akpınar, Ozgur Tosun, Cem Comunoglu.

c Date of publication, distribution, etc 2013.

b Name of publisher, distributor, etc Elsevier Inc.

a Summary, etc Objective Any distinction and the usefulness of semiquantitative parameters derived from dynamic-contrast-enhanced (DCE) MRI obtained with extracellular gadolinium contrast agent in hemangiomas, hepatocellular carcinomas (HCC) and metastases of the liver was studied prospectively. Methods Seventy-four focal liver lesions (consisted of 34 hemangiomas, 23 HCC, and 17 metastases) of the 37 patients underwent DCE–MRI (six phases). Functional coloured maps and subsequently semiquantitative parameters were obtained using the FuncTool. Maximum and average (avg) values of mean time to enhancement (MTE), positive enhancement integral (PEI), time to peak (TP), maximum slope of increase (MSI), maximum slope of decrease (MSD) values were measured by placing the region of interest. The diagnosis of HCC and metastases were proven histopathologically and/or clinically. Results The mean values of the paremeters were: In hemangiomas, avgMTE: 271.2±4.7; avgPEI: 840.3±77.3; avgTP: 146.6±13.1; avgMSI: 999.1±108.4; avgMSD: 254.1±30.4. In HCC, avgMTE: 246±3.6; avgPEI: 424.9±31.6; avgTP: 132.8±9.5; avgMSI: 484.1±36.5; avgMSD: 109.1±13.3. In metastases, avgMTE: 248.1±8.2, avgPEI: 453.9±39.6; avgTP: 142.8±13.9; avgMSI: 472.6±50.4 and avg MSD: 200.1±38.2. Both maximum and avg values of MTE, PEI, MSI, and MSD were significantly higher in hemangiomas (P<.05). The most significant difference was found in avgPEI with 82.1% sensitivity and 67.6% specificity when 570 cutoff value was considered. The values however were not significantly different among HCC and metastases (P>.05). Conclusions Semiquantitative DCE–MRI parameters provide useful, complementary, and quantitative information. This technique increases diagnostic value of extracellular gadolinium contrast agent to characterize focal liver lesions and may be useful for follow-up after local–regional therapies.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Radiology

t Title Clinical Imaging

g Relationship information July-August 2013 37(4):692-696

x International Standard Serial Number 08997071

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.clinimag.2013.01.012